Biology of Immunomodulators
Abstract
A number of pyrimidinones were compared for their effects on the reticuleondothelial system (RES) function, macrophage cytotoxicity, prostaglandin secretion, serum interferon levels and resistance to herpes, Aichi and Banzi virus infections. Five of these agents (ABPP, ACPP, AIPP, ABMFPP and ACDFPP) stimulated the RES function when tested two days after treatment. However, their effects were not as pronounced four days post treatment. They also caused a reduction in prostaglandin secretion by macrophages when given 2, 4, and 7 days before sampling. ABPP, ACPP and ABMFPP but no AIPP and ACDFPP rendered macrophages cytotoxic. Five of the pyrimidinones tested caused an elevation in serum interferon levels which peaked between one and two days after treatment. However, the magnitude of the response varied with the drug; ACPP and ABMFPP were most effective in enhancing resistance against BAnzi virus induced encephalitis. Four of the drugs (ACPP, AIPP, ABMFPP and ACDFPP) increased resistance when given prophylactically and three (ABPP, ABMFPP and ACDFPP) when given on the day of challenge. In the herpes virus encephalitis model, only ABPP was effective and only prophylactically. Likewise, only ABMFPP had some effect in the influenza model and only on the day of challenge. Keywords: Immunoenhancing drugs; Viruses; Vaccines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1988
- Accession Number
- ADA213266
Entities
People
- Abdul Ghaffar
- Eugene P. Mayer
- J. D. Gangemi
Organizations
- University of South Carolina