Discovery and Development of Therapeutic Drugs Against Lethal Human RNA-Viruses: A Multidisciplinary Assault

Abstract

The grant funds have been sharply focused on discovery of new antiviral drugs. We have been pursuing the pancratistatin family of antiviral leads as a top priority. The research results here have been very encouraging and pancratistatin, isonarciclasine, cis-dihydronarciclasine as well as trans-dihydronarciclasine have proved to be quite promising. Meanwhile over 1700 naturally occurring specimens are now undergoing preliminary antiviral evaluation at USAMRIID. The resulting leads will also be pursued as rapidly as financial resources permit. The most exciting overall result has been the discovery in USAMRIID's laboratories that pancratistatin will cure the in vivo experimental version of Japanese Encephalitis. Keywords: RAI; Antivirals; Natural products; RNA viruses; RNA-type antiviral drugs; Naturally occurring antiviral drugs. (KT)

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Document Details

Document Type
Technical Report
Publication Date
Aug 21, 1989
Accession Number
ADA213392

Entities

People

  • George R. Pettit

Organizations

  • Arizona State University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Herpesviridae Infections
  • Medical Personnel
  • Organic Chemistry
  • Rna Viruses
  • Virus Diseases
  • Viruses

Readers

  • Systems Analysis and Design
  • Virology (or Medical Virology).