Immunologic Mechanisms of HTLV-3 Infection, Role of Autoimmunity in Aids
Abstract
Infection with Human Immunodeficiency Virus type 1 (HIV-1), the etiologic agent of the acquired immune deficiency syndrome (AIDS), is increasing at an epidemic rate. The severity of immunologic impairment of infected individuals spans a broad range. It is not currently known whether this heterogeneity reflects distinct outcomes of infection or whether infection progress to a common endpoint at different rates. Developing closer knowledge of immunological events that precede the onset of frank AIDS, as well as the interplay between HIV, immunity and the hematopoietic elements that give rise to the attempts to develop better therapeutic approaches to AIDS. This proposal focuses on two primary areas. The first section, Interaction of HIV-1 and Bone Marrow, focuses on hematopoietic progenitor cells as possible reservoirs of virus. It is designed to explore the relationship between acquisition of lineage specific differentiated function and viral permissiveness, and examine the interaction of infected myeloid and lymphoid cells as they affect immune function and regulation of bone marrow growth. Our second research goal has been the Evaluation of Immunologic Changes Related to Progression of HIV Infection. This aspect of our research draws on the resources of two large prospective cohort studies of the natural history of HIV infection, one in gay/bisexual men (SHARE) and one in intravenous drug users (ALIVE).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 05, 1989
- Accession Number
- ADA213591
Entities
People
- Albert D Donnenberg