Effects of Cytoskeletal Reagents Upon Stretch Activated Channels in Chick Skeletal Muscle

Abstract

We have developed the hardware and software to evaluate stress and strain in patch-clamped membranes. We found that there is lipid flow during stress in the patch and therefore is not under significant steady stress and stress must be transferred through the cytoskeleton. We have also developed techniques to study the ultrastructure of the patch using high voltage electron microscopy. Keywords: Membranes; Channels; Cytoskeleton; Video microscopy; Stress; Strain; Patch clamp.

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Document Details

Document Type
Technical Report
Publication Date
Sep 06, 1989
Accession Number
ADA213676

Entities

People

  • Frederick Sachs

Organizations

  • State University of New York at Albany

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Cell Membrane
  • Cells
  • Cytoskeleton
  • Electron Microscopes
  • Electron Microscopy
  • Electrons
  • High Resolution
  • High Voltage
  • Membranes
  • Microscopy
  • Military Research
  • Skeletal Muscle
  • Tissues
  • Voltage

Fields of Study

  • Engineering

Readers

  • Cardiovascular Physiology
  • Computer Science/Computer Engineering/Data Science/Digital Signal Processing.
  • Molecular Biology and Genetics

Technology Areas

  • Microelectronics
  • Microelectronics - Microelectromechanical Systems