Relationship Between Organophosphate Toxicity and Choline Metabolism

Abstract

Although research on the organophosphate cholinesterase (Ch/E) inhibitors has focused primarily on inhibition of acetylcholinesterase (AChE) and enhanced cholinergic transmission, these actions alone cannot explain the biochemical and physiological effects that persist long after enzyme activity has returned to normal. Although evidence indicates that some organophosphates alter the disposition and metabolism of choline and choline-containing compounds in the nervous system, the relationship of these changes to the toxicological manifestations of ChE inhibition has not been investigated. Organophosphate cholinesterase inhibitors; Brain; Choline; Acetylcholine; Lipids; Phospholipids; Acetylcholinesterase; Convulsions; Phospholipases; Chemical warfare agents.

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Document Details

Document Type
Technical Report
Publication Date
Jun 06, 1986
Accession Number
ADA213881

Entities

People

  • Lynn Wecker

Organizations

  • LSU Health Sciences Center New Orleans

Tags

DTIC Thesaurus Topics

  • Anticonvulsants
  • Brain
  • Cell Membrane
  • Cells
  • Central Nervous System
  • Chemistry
  • Enzyme Inhibitors
  • Epilepsy
  • Fatty Acids
  • Medical Personnel
  • Metabolism
  • Nervous System
  • Peripheral Nervous System
  • Rodents
  • Seizures
  • Skeletal Muscle

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Neurotoxicology