Carboxyalkylated Hemoglobin as a Potential Blood Substitute

Abstract

Our emphasis has been on two major objectives. We have determined the properties of the carboxymethyl derivative of hemoglobin to determine whether they are consistent with its possible future use as a blood substitute. We have evidence that this derivative is analogous to that formed in the reaction of hemoglobin with CO2. This natural product results in a very low oxygen affinity for hemoglobin, which is a very desirable property for a blood substitute. The second major objective of our research has been to cross-link this hemoglobin derivative in a manner that will maintain the essential functional properties of hemoglobin. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Sep 20, 1989
Accession Number
ADA213886

Entities

People

  • James M. Manning

Organizations

  • The Rockefeller University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylation
  • Albumins
  • Biomedical And Dental Materials
  • Blood Substitutes
  • Chemistry
  • Chlorides
  • Contracts
  • Filtration
  • Gel Electrophoresis
  • Laboratory Animals
  • Magnesium Compounds
  • Materials
  • Molecular Weight
  • Molecules
  • Polymeric Films
  • Proteins
  • Security

Fields of Study

  • Mathematics
  • Medicine

Readers

  • Molecular and Cellular Biochemistry