2ND Annual Report on Contract N00014-88-K-0059
Abstract
There is abundant evidence suggesting that catecholamines administered centrally can regulate adrenocorticotropin (ACTH) and vasopressin (AVP) release. Because there is a heavy catecholaminergic projection from the brainstem innervating the paraventricular nucleus (PVN) of the hypothalamus, the nuclear region that regulates AVP and ACTH release from the pituitary, it has been suggested that catecholaminergic regulation of the ACTH and AVP may occur directly at this site. The catecholaminergic cell groups in the brainstem that project to the paraventricular nucleus are located in regions shown to be involved in the baroreflexes and the regulation of arterial blood pressure and heart rate during hemorrhage. Recently, type II glucocorticoid receptors have been found on catecholaminergic cell groups in the brainstem. Coupled with the findings that ACTH and AVP immunostaining and mRNA levels are altered after adenalectomy, these data suggest that the responses of plasma ACTH and AVP and the recovery of arterial blood pressure and heart rate after hemorrhage and the baroreflex, may be influenced by glucocorticoids which may work though these catecholaminergic cell groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1989
- Accession Number
- ADA213918
Entities
People
- Daniel N. Darlington
- Mary F. Dallman
Organizations
- University of California, Berkeley