Cold Injury - Pharmacologic Prevention

Abstract

The objective of this study was: 1. To develop an animal experimental model that would allow quantitative evaluation of tissue loss secondary to local cold exposure (frostbite), such that measures of possibly protective value could be evaluated. 2. To determine whether such frostbite injury is a rewarming injury rather than tissue damage due solely to cold or freezing. 3. To determine the pathogenesis of the rewarming injury, specifically, whether associated with: a. Superoxide release; b. Complement activation; c. Leukoembolus; d. Prostaglandin or prostacyclin activity; e. Other non-specific aspects of the inflammatory response blocked by steroids or non-steroidal anti-inflammatory agents; and f. Platelet aggregation. 4. To evaluate the timing of administration of any agent found to be protective to determine whether they are effective if given prior to, during, or after cold exposure. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Aug 22, 1984
Accession Number
ADA213932

Entities

People

  • Ben Eiseman

Organizations

  • University of Colorado Health

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Anatomy
  • Availability
  • Biomedical Research
  • Blood Cells
  • Buildings And Structures
  • Classification
  • Cooling
  • Free Radicals
  • Frostbite
  • Leukocytes
  • Nitrogen
  • Nitrogen Mustards
  • Pharmacologic Actions
  • Security
  • Sulfur Compounds
  • Superoxides

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Materials Science
  • Trauma Surgery or Emergency Medicine.