Treatment of Laser Induced Retinal Injuries

Abstract

Previously we have shown that the ocular response to laser-induced ocular injury is characterized by an enhancement in arachidonic acid metabolism and that steroid treatment curtailed this response. In the present study we investigated the involvement of leukotrienes B4 (LTB4) and the following parameters were studied: LTB4 production by the retina/choroid, its accumulation in the vitreous, and changes in vitreal protein levels. The effect of an antileukotriene drug on the severity of the ocular inflammatory response was also studied. Our finding that the ocular response to laser-induced retinal injury involves an enhanced leukotriene B4 response, might be responsible for edema formation and accumulation of various toxic substances in the vitreous, with resultant immediate incapacitation of the affected individuals. Treatment to reduce leukotriene production might attenuate vision reduction. Keywords: Vitreal protein levels; Neodymium; YAG laser; Leukotriene B4; Blood retinal barrier; RA III.

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Document Details

Document Type
Technical Report
Publication Date
Jun 21, 1989
Accession Number
ADA214006

Entities

People

  • Michael Belkin
  • N. Naveh

Organizations

  • Tel Aviv University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Inflammatory Agents
  • Blood
  • Cerebral Edema
  • Classification
  • Diseases And Disorders
  • Energy Levels
  • Experimental Design
  • Eye
  • Eye Injuries
  • Incapacitation
  • Laser Applications
  • Laser Safety
  • Lasers
  • Tissues
  • Uvea
  • Yag Lasers

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Optical Physics and Photonics.

Technology Areas

  • Directed Energy