Models of Excitation-Secretion Coupling in Pituitary Cells
Abstract
This report describes initial progress in developing a biophysical description of the electrical events surrounding hormone release in pituitary cells. Utilizing a model based on a membrane capacitance shunted by potassium and calcium channels, we are developing a computer program that will stimulate the dynamic response of the transmembrane potential of GH3 cells in response to thyrotropia-releasing hormone (TRH). When available, we are using published channel models of potassium and calcium channels. In parallel, we are persuing a phase-plane description of the electrical properties. These models and analyses will be used to investigate the effect of temperature on membrane action potentials. Keywords: Biophysiology; Mathematical model; Ion channel; GH3 cell; Neural model. (kt)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 25, 1989
- Accession Number
- ADA214180
Entities
People
- C. F. Starmer
Organizations
- Duke University Hospital