Dermal Sensitization Potential of Nitrosoguanidine in Guinea Pigs

Abstract

Nitrosoguanidine was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence of nitrosoguanidine-induced sensitization was obtained in the study. Keywords: Triple base propellants; Dermal sensitization; Nitrosoguanidine; Mammalian toxicology; Guinea pigs; Buehler test; Nitroguanidine. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214263

Entities

People

  • Denzil F. Frost
  • Don W. Korte Jr.
  • Earl W. Morgan
  • James D. Justus

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Body Weight
  • Composite Propellants
  • Health
  • Health Services
  • Laboratory Animals
  • Materials
  • Nitroso Compounds
  • Propellants
  • Quarantine
  • Rodents
  • Spectra
  • Test And Evaluation
  • Triple Base Propellants
  • United States

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology