Primary Ocular Irritation Potential of Nitrosoguanidine in Male Rabbits

Abstract

The potential for nitrosoguanidine to produce primary eye irritation was evaluated in male New Zealand White rabbits by using a modified Draize method. Slight conjunctival vasodilation (indicative of mild inflammation) was the predominant response observed. Slight iridial hyperemia was noted in one animal and one animal had a small fluorescein-staining area in the cornea. The results indicate that nitrosoguanidine is not a primary ocular irritant under conditions of this study. Keywords: Triple base propellants; Nitrosoguanidine; Ocular irritation; Mammalian toxicology; Rabbit; Munitions; Propellants; Nitroquanidine.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214264

Entities

People

  • Don W. Korte Jr.
  • Gerald F. Hiatt

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animal Structures
  • Biological Staining And Labeling
  • Biomedical Research
  • Blood Vessels
  • Classification
  • Cornea
  • Eye
  • Health Services
  • Inflammation
  • Materials
  • Medical Personnel
  • New Zealand
  • Nitroguanidine
  • Propellants
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology