Acute Oral Toxicity of Nitrosoguanidine in Sprague-Dawley Rats

Abstract

The acute oral toxicity of nitrosoguanidine was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The median lethal dose for both male and female Sprague-Dawley rats was greater than 5000 mg/kg. Major clinical signs were red nasal staining, yellow perianal staining, irritability, diarrhea, ataxia, and inactivity. These signs were minimal in severity and occurred primarily during the first 24 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place nitrosoguanidine in the practically non-toxic class. Keywords: Triple base propellants; Mammalian Toxicology; Rat; Munitions; Nitroguanidine. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214312

Entities

People

  • Conrad R. Wheeler
  • Don W. Korte Jr.
  • Earl W. Morgan

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Biomedical Research
  • Body Regions
  • Body Weight
  • Classification
  • Diarrhea
  • Health
  • Health Services
  • Laboratory Animals
  • Lethal Dosage
  • Materials
  • Medical Personnel
  • Movement Disorders
  • Nitroso Compounds
  • Toxicity
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology