Acute Oral Toxicity of Nitrosoguanidine in ICR Mice

Abstract

The acute oral toxicity of nitrosoguanidine was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose was greater than a limit dose of 5000 mg/kg. Clinical signs observed were yellow perianal stains in 2 to 5 males and irritability in 1 of 6 females. These signs were minimal in both severity and duration. According to the classification scheme of Hodge and Sterner, these results place nitrosoguanidine in the practically nontoxic class of chemicals. Keywords: Triple base propellants; Acute oral toxicity; Nitrosoguanidine; Mammalian toxicology; Mouse; Propellants; Nitroguanidine; (kt)

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214313

Entities

People

  • Conrad R. Wheeler
  • Don W. Korte Jr.
  • Earl W. Morgan

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Availability
  • Biomedical Research
  • Body Weight
  • California
  • Classification
  • Health
  • Health Services
  • Lethal Dosage
  • Materials
  • Medical Personnel
  • Nitroguanidine
  • Preventive Medicine
  • Propellants
  • Security
  • Toxicology
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology