Acute Dermal Toxicity of Nitrosoguanidine in Rabbits

Abstract

The acute dermal toxicity of nitrosoguanidine, was evaluated in five male and five female New Zealand White rabbits. Nitrosoguanidine (2g/kg) was applied topically to the clipped dorsal skin surface under a semi-occlusive wrap for 24 hours. There was no evidence of systemic toxicity or death. Nine of the rabbits exhibited slight to moderate erythema after wrap removal and all had cleared by 24 hours. Slight erythema was also observed in 3 rabbits 48-72 hours after wrap removal. These data indicate that nitrosoguanidine does not produce systemic toxicity when administered by 24-hour topical application at a limit dose of 2 g/kg. Keywords: Triple base propellants; Acute dermal toxicity; Nitrosoguanidine; Rabbit; Mammalian toxicology; Nitroguanidine.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214314

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan
  • James D. Justus

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Body Weight
  • Chemical Analysis
  • Classification
  • Health
  • Health Services
  • Materials
  • Medical Personnel
  • New Zealand
  • Nitroguanidine
  • Preventive Medicine
  • Propellants
  • Security
  • Toxicity
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology