Primary Dermal Irritation Potential of Nitrosoguanidine in Female Rabbits

Abstract

The primary dermal irritation potential of nitrosoguanidine was determined in female New Zealand White rabbits by using a modified Draize method. Two nitrosoguanidine skin application sites were evaluated on each animal following a 4-hour application to closely clipped skin. Very slight erythema was observed in 2 rabbits at test compound sites and in one rabbit at the vehicle control site by 1/2 hour after wrap removal. All rabbits had returned to normal by 24 hours after dosing. Neither edema nor any other recognizable skin reaction was detected at any time during the 14-day observation period. Nitrosoguanidine was classified as a nonirritant under conditions of this study. Keywords: Triple base propellants; Primary dermal irritation; Nitrosoguanidine; Propellant; Mammalian toxicology; Rabbit; Nitroguanidine. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA214315

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Classification
  • Health
  • Health Services
  • Materials
  • Medical Personnel
  • New Zealand
  • Nitroguanidine
  • Pathology
  • Personnel Management
  • Preventive Medicine
  • Propellants
  • Quarantine
  • Security
  • Toxicity
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology