Subchronic Studies of Chlorotrifluorethylene
Abstract
A single application of CTFE (3.1 oil) to intact rabbit skin produced no signs of irritation, however, continued skin contact did produce a mild allergic response in guinea pigs. The fluid produced mild conjunctival redness in rabbit eyes one hour following application but this was resolved by 24 hours. It can be assumed that the fluid not be irritating to human skin but would be irritating upon accidental eye contact. Washing eyes immediately after contact does not preclude the transient irritating effects. Repeated inhalation of CTFE vapors and aerosol, 6 hrs/d, 5 d/wk, 90 d resulted in treatment-related depression of body weight gains throughout the study, particularly in the male rat groups. The depression in body weight gain of the treated male rats was greatest during the 22-71 day period. Alkaline phosphatase, AST, and ALT values examined at the conclusion of the study indicated a treatment-response effect in the male test rats but not in the female test rats. Relative kidney and liver weights of test male and female rats were significantly elevated when compared to the respective control groups. The primary target organ of CTFE was the liver. Gross liver hypertrophy and microscopic hepatocytomegaly were the principal manifestations of CTFE-induced hepatotoxicity. Dose-response data from these studies indicated the need for additional exposures at lower concentrations to identify a no-effect level.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1989
- Accession Number
- ADA214619
Entities
People
- B. T. Culpepper
- E. C. Kimmel
- E. R. Kinkead
- S. S. Henry
- V. L. Moroughan