Evaluation of the Acute Toxicity of Silahydrocarbon
Abstract
Silahydrocarbon (SHC) is a base stock for a candidate high-temperature hydraulic fluid. A complete battery of acute toxicity tests were performed to determine the potential health hazard of the fluid. A single neat dose of 0.1 mL SHC into NZW rabbit eyes resulted in slight conjuctivae irritation one hour after treatment in all unflushed eyes and one of three flushed eyes. Conjunctival irritation persisted through 24-hours but was dissipated by 48 hours. Rinsing the eyes after treatment was of questionable benefit. Single treatment of 0.5 mL neat SHC to rabbit skin produced negative results for all but a single animal, which had very slight erythema at the test site 48 hours after treatment. Guinea pigs failed to elicit a sensitization response following repeated application of SHC. A single oral dose of 5g SHC/kg of animal body weight to five male and female F-344 rats, and a single dermal application of 2g SHC/kg body weight applied to five male and five female NZW rabbits resulted in no deaths. No signs of toxic stress were observed, and all animals gained weight during the 14-day post-treatment observation periods. Inhalation exposure to SHC was performed by exposing five male and five female F-3444 rats to a 4.8 mg/L near limit concentration of aerosolized SHC for four hours. All surviving rats gained weight during the 14-day post-treatment observation period. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1989
- Accession Number
- ADA214780
Entities
People
- C. R. Doarn
- E. R. Kinkead
- R. E. Wolfe
- S. K. Bunger