Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs

Abstract

The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1989
Accession Number
ADA215151

Entities

People

  • Don W. Korte Jr.
  • Larry D. Brown
  • Yvonne C. Letellier

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Body Weight
  • Health
  • Health Services
  • Laboratory Animals
  • Materials
  • Materials Laboratories
  • Medical Personnel
  • Observation
  • Preventive Medicine
  • Propellants
  • Rodents
  • Solid Propellants
  • Spectra
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology