Effects of Estradiol and Progesterone on Rat Intestinal and Hepatic Phospholipase A Activity

Abstract

Small intestine and liver play major roles in lipid and lipoprotein metabolism. Both organs contain high activities of phospholipase A, but little is known regarding the hormonal regulation of this enzyme in these tissues. In the present study, phospholipase A activity was measured in male rats treated with subcutaneous injections of 17 beta-estradiol or progesterone. Estradiol treatment (0.6 mg/day for 14 days) decreased intestinal and hepatic phospholipase A activities by 65% and 53%respectively. Administration of estradiol reduced the specific activity of the enzyme in both microsomal and cytosol fractions of the intestinal mucosa. In contrast to the effects of estradiol, progesterone administration (2 mg/day for 14 days) increased phospholipase A activity in intestinal and hepatic tissue by 2.4- and 2.1- fold, respectively. Sex hormones; Phospholipase A; Lipoproteins; Amnion; Chorioallantois; Corticotropin. (jes)

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1988
Accession Number
ADA215442

Entities

People

  • D. Maor
  • K. M. Shakir
  • S. L. Gartner
  • Simeon Margolis

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Animals
  • Biomedical Research
  • Body Weight
  • Cellular Structures
  • Governments
  • Hormones
  • Intestines
  • Laboratory Animals
  • Lipid Metabolism
  • Lipids
  • Navy
  • Security
  • Sex Hormones
  • Small Intestine
  • Statistical Analysis
  • Subcellular Fractions

Fields of Study

  • Biology
  • Computer science

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.