Toxicology Studies on Lewisite and Sulfur Mustard Agents: Genetic Toxicity of Sulfur Mustard (HD) in Chinese Hamster Ovary Cells
Abstract
The cytotoxic, clastogenic and mutagenic effects of sulfur mustard in Chinese hamster ovary cells are described in this report. The cytotoxicity data indicate that micromolar amounts of HD are highly toxic in micromolar amounts. Chromosome aberration frequencies increased in a dose -dependent manner over a dose range of 0.5 to 1.0 um and SCE increased in a dose-dependent fashion in the dose range of 0.0625 to 0.25 uM. Mutation induction at the HGPRT locus was sporadic, but the majority of the exposure resulted in mutation frequencies which were 1.2 to 4.3 fold higher than the spontaneous frequencies. Keywords: Sulfur mustard; Chinese hamster ovary cells; Genetic toxicity; Mutagenicity ;In vitro tests; Lab animals; RA5. (KT)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1989
- Accession Number
- ADA215475
Entities
People
- L. B. Sasser
- R. F. Jostes Jr.
- R. J. Rausch