Effect of Propranolol on Metabolic Responses to Exercise at High Altitude

Abstract

Sea-level (SL) residents sojourning at high altitude (HA) experience a metabolic adaptation resulting in reduced muscle glycogen use during submaximal exercise compared compared to SL exercise of the same duration and percent maximal O2 uptake. Glycogen-sparing was hypothesized to result from chronic sympathetic nervous stimulation at HA. The present study aimed to determine if beta-adrenergic blockade during HA acclimatization would prevent this metabolic adaptation. The data confirm that HA acclimatization results in a decrease in both glycogen utilization and lactate accumulation during submaximal exercise; however, beta-adrenergic blockade did not prevent the glycogen-sparing adaptation. In addition, propranolol reduces plasma lactate accumulation during submaximal exercise at HA, which is the same effect as has been reported at SL. Keywords: Catecholimine; Beta adrenergic; Blockade. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1988
Accession Number
ADA215553

Entities

People

  • Allen Cymerman
  • Andrew J Young
  • Lorne G. Moore
  • Patricia M. Young
  • Robert E. Mccullough

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Altitude
  • Altitude Acclimatization
  • Carbohydrates
  • Catecholamines
  • Endocrine Glands
  • Epinephrine
  • Fatty Acids
  • Glycogen
  • Glycolysis
  • Health Services
  • Heart
  • Heart Rate
  • High Altitude
  • Metabolism
  • Nervous System
  • Sea Level
  • Skeletal Muscle

Readers

  • Cardiovascular Physiology
  • Exercise and Sports Science.