Studies of Wound Healing in the Presence of an Angiogenesis Factor

Abstract

Basic fibroblast growth factor (bFGF) was found to increase wound healing in a healing-impaired model; the db/db mouse. When bFGF was applied to 6 mm punch biopsy wounds, a dramatic increase in granulation tissue formation was observed. bFGF-treated wounds appeared very similar to control normal wounds in respect to dermal thickness, compactness of dermis, numbers of migratory cells and number of capillaries. No effect on the epidermis was observed. We conclude, therefore, that bFGF may be a useful modality for the treatment of wounds in healing-impaired or healing-compromised patients. Keywords: Angiogenesis growth factors. (aw)

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Document Details

Document Type
Technical Report
Publication Date
Jul 14, 1989
Accession Number
ADA215886

Entities

People

  • Daniel B. Rifkin

Organizations

  • NYU Langone Health

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Bandages
  • Blood
  • Cells
  • Classification
  • Connective Tissue
  • Endothelial Cells
  • Fibroblasts
  • Growth Factors
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Rodents
  • Security
  • Tensile Strength
  • Wound Healing

Fields of Study

  • Biology
  • Medicine

Readers

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