Arginine Vasopressin Lowers Pulmonary Artery Pressure in Hypoxic Rats by Releasing Artrial Natriuretic Peptide
Abstract
We previously demonstrated that arginine vasopressin (AVP) lowers pulmonary artery pressure in rats with hypoxic pulmonary hypertension by activation of the V1 receptor. The pulmonary depressor effect of AVP in hypoxia adapted rats is not due to its effect on cardiac output. The current study tested two alternative hypotheses: that AVP lowers pulmonary artery pressure in the hypoxia adapted lung by 1) dilating pulmonary vasculature directly, or 2) releasing atrial natriuretic peptide (ANP) from the heart. The first hypothesis was tested by injecting AVP into the pulmonary arteries of isolated, buffer perfused lungs and monitoring pulmonary artery pressure, and by exposing preconstricted pulmonary artery rings to graded doses of AVP and monitoring the tension generated. AVP caused minimal vasodilation in prefused lungs and only a small vasodilator effect in pulmonary artery rings. The second hypothesis was tested by injecting AVP (160 ng/kg) or vehicle intravenously in conscious hypoxia adapted (4 weeks) or air control rats and measuring ANP in arterial blood and atria, and by testing pretreatment with the V1 receptor antagonist D(CH2)5 Tyr (Me) AVP (130 micrograms/kg) on the AVP-induced increase in plasma ANP. AVP produced a 7-fold increase in plasma ANP in hypoxia adapted rats and a 5-fold increase in ANP in air controls. ANP release was abolished by pretreatment of both groups with d(CH2)5 Tyr(Me)AVP. Keywords: Tyrosine; Methyl radicals. (kt)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 06, 1988
- Accession Number
- ADA215986
Entities
People
- Hongkui Jin
- Ren-hui Yang
- Robert M. Jackson
- Thomas M. Mckenna
- Yiu-fai Chen
Organizations
- Naval Medical Research Center