Visual Experience Regulates Gene Expression in the Developing Striate Cortex
Abstract
We have examined the regulation of expression of the genes for the neuronal growth associated protein GAP43, the type II calcium (calmodulin dependent protein kinase, and glutamic acid decarboxylase) in the kitten visual cortex during normal development and following a period of visual deprivation. We find that these genes, which display very different patterns of expression during normal development, are all up-regulated in the visual cortex of animals reared in the dark. Upon exposure to light, the expression of one of these genes drops to near-normal levels within 12 hours. (SDW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1989
- Accession Number
- ADA216149
Entities
People
- Mark Bear
- Rachael L. Neve
Organizations
- Brown University