Clearance, Distribution, and Elimination of the Brevetoxin PbTx-3 in Rats

Abstract

After intravenous administration, 3HpbTx-3 was rapidly cleared from the blood; less than 10% remained after 1 min. Within 30 min, radiolabel distributed to skeletal muscle (69.5%), liver (18.0%), and intestinal tract (8. 0%). Over 24 hr, radiolabel decreased in muscle, remained constant in liver, and increased in the intestinal tract and feces. Elimination occurred via feces (75. 1%) and urine (14.4%), with 9.0% remaining in the carcass after 6 days. This distribution and elimination profile suggested that liver was the major organ of metabolism and that biliary excretion was an important route of elimination. Thin-layer chromatography confirmed the presence of brevetoxin metabolites in fecal extracts. Skeletal muscle does not appear to be a site of metabolism, but a storage compartment, from which toxin is slowly released prior to clearance by the liver. These studies are the first demonstration of in vivo brevetoxin metabolism in mammals.

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Document Details

Document Type
Technical Report
Publication Date
Oct 19, 1989
Accession Number
ADA216166

Entities

People

  • C. B. Templeton
  • J. F. Hewetson
  • Mark A. Poli
  • W. L. Thompson

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Biomedical Research
  • Blood
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Diseases And Disorders
  • Ecology
  • Infectious Diseases
  • Materials
  • Membrane Potentials
  • New York
  • Research Facilities
  • Skeletal Muscle
  • Thin Layer Chromatography
  • Tissues
  • United States

Fields of Study

  • Biology
  • Computer science

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology