Toxicology Studies on Lewisite and Sulfur Mustard Agents: Two-Generation Reproduction Study of Sulfur Mustard (HD) in Rats
Abstract
Chemical warfare agents present an obvious risk to individuals suffering acute exposure, but they may also present long-term environmental or occupational health hazards for workers in operations involving these chemical agents. Comprehensive data are not available to evaluate the potential reproductive risk from long-term exposure to sulfur mustard (HD), (bis(2- chloroethyl)sulfide). Groups of rats (27 females and 20 males/group/generation) were gavaged with 0, 0.03, 0.1 or 0.4 mg/kg HD for 13 weeks prior to mating, and throughout gestation, parturition and lactation in a 42-week two-generation study. Growth of adult F(1) rats of both sexes was reduced by the 0.4 mg/kg in either generation. Although not different lactation. A dose-related lesion of the squamous epithelial mucosa of the forestomach was observed in both sexes. The lesion was characterized by thickening of the squamous with varying degrees of hyperkeratosis. Benign neoplasms of the forestomach were found in about 10% of the intermediate (8/94) and high (10.94) dose groups. The NOEL for toxicity in this study was <0.03 mh/kg and for reproductive effects was >0.4 mg/kg.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1989
- Accession Number
- ADA216423
Entities
People
- D. R. Kalkwarf
- J. A. Cushing
- L. B. Sasser
- R. L. Buschbom
- Rachel A. Miller