A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma

Abstract

Prostaglandins may play a central role in the protein catabolic response following injury. Following operative injury, blocking prostaglandin generation reduced nitrogen excretion and tended to diminish hind leg amino acid flux. PGE2 infusion increased skeletal muscle amino acid flux. Altering leg blood flow by sympathectomy and nerve stimulation failed to alter skeletal muscle protein breakdown. High dose narcotic anesthesia tended to inhibit catabolic responses, suggesting that the central nervous system is important in these responses. Prostaglandin inhibition should be evaluated as a method of reducing the response to injury in humans. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Nov 25, 1989
Accession Number
ADA216569

Entities

People

  • Douglas W. Wilmore

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anesthesia
  • Arteries
  • Biological Sciences
  • Blood
  • Blood Flow
  • Cardiovascular Physiological Phenomena
  • Catabolism
  • Central Nervous System
  • Chemistry
  • Contracts
  • Health Services
  • Monitoring
  • Nervous System
  • Security
  • Skeletal Muscle
  • Veins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology