Analysis of the Human T Cell Response to HTLV-III

Abstract

Acquired Immune Deficiency Syndrome is marked by a collapse in immune responses, particularly those mediated by thymus-derived (T) lymphocytes. Nevertheless, the presence of antibodies to the AIDS virus (HIV) indicates the presence of virus specific T cells. Over the last year we have defined cell tumors and populations which are much less susceptible to virus mediating killing. We are currently investigating how cells differ in the sensitivity to virus and how we can utilize this information therapeutically. Keywords: RA I; Lab animals; Rats; Volunteers; Vaccine development; Cellular immunity; Human immunodeficiency virus; Virology AIDS; Biotechnology; Monoclonal antibodies; Vaccines.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1989
Accession Number
ADA216701

Entities

People

  • Robert W. Finberg

Organizations

  • Dana–Farber Cancer Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquired Immune Deficiency Syndrome
  • Amino Acids
  • Anti-Bacterial Agents
  • Blood
  • Blood Cells
  • Cell Line
  • Cells
  • Classification
  • Contracts
  • Hiv Infections
  • Infection
  • Laboratory Animals
  • Lymphocytes
  • Molecules
  • Proteins
  • Security
  • Viruses

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech