Ultrastructural and Cytochemical Evaluation of the Cytotoxicities of Trimethylpentane on Rat Renal and Hepatic Tissues

Abstract

The primary objective of the present investigation is to determine the acute cytopathological effects of trimethyl-pentane on the hepatic and renal tissues of the sexually mature male rat. Specifically, the first year of the project is designed to evaluate, cytochemically, the activity of lysosomes associated with kidney cells of the proximal convoluted tubule, to determine by means of ferritin tracers whether the glomerular basement membrane has been compromised, and to analyze by scanning electron microscopy various regions of the kidney for manifestations of cellular toxicity.

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Document Details

Document Type
Technical Report
Publication Date
Apr 29, 1985
Accession Number
ADA216820

Entities

People

  • William N. Norton

Organizations

  • Southeastern Louisiana University

Tags

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Body Weight
  • Cells
  • Cyclic Hydrocarbons
  • Electron Microscopes
  • Electron Microscopy
  • Electrons
  • Epithelial Cells
  • Hydrocarbons
  • Kidneys
  • Membranes
  • Microscopes
  • Microscopy
  • Scanning
  • Scanning Electron Microscopes
  • Scanning Electron Microscopy
  • Transmission Electron Microscopy

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics