Interferon Induced Transfer of Viral Resistance
Abstract
The overall objective was the continued study of the cells, mechanism and molecules involved in the transfer of interferon induced resistance to viruses. Previous studies during the first granting period led to a probable model that an interferon-donor cell membrane interaction generates secondary messenger molecule(s) which transmit the interferon signal from the membrane to the nucleus. This molecule(s) in turn is transferred to the recipient cell and causes depression of it's gene for the antiviral protein. These findings have shown that: (a) the transfer process is an important major amplification system for interferon's antiviral and immunosuppressive actions; (b) the transfer process is a means to study cell communication, genetic derepression and their molecular control; (c) there is a new process for cells of the immune system to disseminate antiviral and immunoregulatory activity; (d) interferon and hormones are very similar in their activities; (e) interferon may be a hormone; (f) hormones may have functions, such as protection of tissues against viruses and maintenance of differentiation, which are not classically associated with them; (g) a transformation sensitive protein (fibronectin) has antiviral activity. The understanding of the molecules involved in the aforementioned processes may lead to a new series of antiviral and immunosuppressive substance as well as a possible new strategy of tissue targeted antiviral and antitumor therapy. Keywords: Interferon; Cell communication; Resistance transfer; Viruses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1980
- Accession Number
- ADA217050
Entities
People
- J. E. Blalock
- Samuel Baron
Organizations
- University of Texas Medical Branch