Interferon Induced Transfer of Viral Resistance

Abstract

The overall objective was the continued study of the cells, mechanisms and molecules involved in the transfer of interferon (IFN) induced viral resistance, immunosuppression and hormonal activity. Studies during the first two granting periods led to a probable model that an IFN-donor cell membrane interaction generates a secondary messenger molecule(s) which transmit the IFN signal from the membrane to the the antiviral protein. These findings show that:nvolvesansfer a new system of recognition of foreigness; f IFN; (d) interferon has broad hormonal activity; (e) hoay be a regulatory circuit between the immune and fibronectin may be involved in the antiviral actionaforementioned processes may lead to acules new series of antiviral and immunosuppressive substances as well as a possible new strategy of tissue targeted antiviral and antitumor therapy. Keywords: Interferon; Cell communication; Resistance transfer; Viruses; Antibody production; Polypeptide hormones; Lymphocytes.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1981
Accession Number
ADA217051

Entities

People

  • J. E. Blalock

Organizations

  • University of Texas Medical Branch

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • B Lymphocytes
  • Biological Factors
  • Biomedical And Dental Materials
  • Blood
  • Cell Line
  • Cell Membrane
  • Cells
  • Chemistry
  • Culture Techniques
  • Immune Serums
  • Immune System
  • Leukocytes
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • T Lymphocytes

Fields of Study

  • Medicine

Readers

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  • Immunology