Interferon Induced Transfer of Viral Resistance
Abstract
The overall objective was the continued study of the cells, mechanisms and molecules involved in the transfer of interferon (IFN) induced viral resistance, immunosuppression and hormonal activity. Studies during the first two granting periods led to a probable model that an IFN-donor cell membrane interaction generates a secondary messenger molecule(s) which transmit the IFN signal from the membrane to the nucleus. This molecule(s) in turn is transferred to adjacent recipient cells and causes depression of their genes for the antiviral protein. These findings show that: (a) transfer of IFN induced viral resistance by lymphocytes involves a new system of recognition of foreigness; (b) both B and T lymphocytes disseminate IFN's antiviral of IFN; (d) interferon has broad hormonal activity; (e) hormones may function as antiviral substance; (f) there may be a regulatory circuit between the immune and neuroendocrine system with IFN-a as an intermediary (g) fibronectin may be involved in the antiviral action of IFN. The understanding of the molecules involved in the aforementioned processes may lead to a new series of antiviral and immunosuppressive substances as well as a possible new strategy of tissue targeted antiviral and antitumor therapy. Keywords: Interferon; Cell communication; Resistance transfer; Viruses; Antibody production; Polypeptide hormones; Lymphocytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1982
- Accession Number
- ADA217052
Entities
People
- J. E. Blalock
Organizations
- University of Texas Medical Branch