Phosphoprotein Regulation of Synaptic Reactivity: Enhancement and Control of a Molecular Gating Mechanism
Abstract
Significant Accomplishments and Research Progress includes: 1) Fatty acid regulators of protein kinase C. We have demonstrates that the regulation of synaptic reactivity is closely associated with phosphorylation of protein F1 and that this phosphorylation depends on the activation of protein kinase C. 2) Endogenous protein inhibitor of protein kinase C. As briefly mentioned in the Progress Report we have discovered an endogenous inhibitor of protein kinase C. 3) Exogenous micro-iontophoretic application of protein kinase C regulators. These experiments have just recently been initiated. In this report I shall describe the techniques used and the rationale for the protocols instituted. 4) Acquisition and Construction of Major Research Equipment. On December 15, 1984 a VAX 11/750 was installed in this laboratory.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 02, 1985
- Accession Number
- ADA217196
Entities
People
- Aryeh Routtenberg
Organizations
- Northwestern University