Acute Oral Toxicity of JA-2 Solid Propellant in ICR Mice
Abstract
The acute oral toxicity of JA-2 Solid Propellant was determined in male and female ICR mice by using an oral gavage, split-dose method. The MLD was 3774.6 + or - 150.5 mg/kg for male mice and 3528.8 + or - 133.8 mg/kg for female mice. JA-2 produced component, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors, inactivity, depression of reflexes, loss of equilibrium, opisthotonus, and increased respiratory activity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included perianal staining, hunched posture, squinting, and rough coat. Most animals exhibited signs by 2 hours after dosing and either had died or the signs had cleared within 5 days of dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class. Keywords: Acute oral toxicity; JA-2 solid propellant; Diethyleneglycol dinitrate; Nitroglycerin; Mammalian toxicology; Propellant; Mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1989
- Accession Number
- ADA217264
Entities
People
- Conrad R. Wheller
- Denzil F. Frost
- Don W. Korte Jr.
- Earl W. Morgan
Organizations
- Letterman Army Hospital