The Molecular Targets of Selected Organophosphorus Compounds at Nicotinic, Muscarinic, GABA, and Glutamate Synapses: Acute and Chronic Studies Including Prophylactic and Therapeutic Approaches
Abstract
The major goals of this project have been: a) to continue our investigation of organophosphorus compounds (OPs) on chemosensitive receptors located at various synapses; b) to attempt to discern the active sites of the receptor-ion channel complexes involved in activation, desensitization and blockade; c) to establish the concentration gradients for various noncompetitive antagonists for production of states of activation, inactivation and blockade of the receptor-channel macromolecule; d) to delineate avenues of testing, in in vivo and in vitro conditions, new agents which may be proven effective in alleviation of symptomatology and intoxication produced by OPs; e) to recommend an agent or combination of agents which will be prophylactically and therapeutically effective against OP intoxication. Keywords: Cholinesterase; Organophosphorus agents; Acetvlcholine; Nicotinic receptor-ion channel complex; Desensitization; Oximes; Irreversible cholinesterase inhibitor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 28, 1988
- Accession Number
- ADA217307
Entities
People
- Edson X. Albuquerque
Organizations
- University of Maryland School of Medicine