Development and Evaluation of Immunomodulators of Hemopoietic and Immunologic Mechanisms

Abstract

During the first year, 14 agents were tested. The most effective agents, taking both prophylactic and therapeutic afficacy, were xerosin, AVS 2776,and AVS 2777. Interleukin 4 was found to induce, Epstein-Barr Virus infected human B cells to produce IgE. IFNg was found in contrast to suppress IgE production. Thus we have identified two lymphokines which regulate IgE production by virus infected human B cells. Keywords: Radioprotective agents; RA I; Mice; IgD; PO; Immunomodulators; Hemopoiesis; Monoclonal antibodies.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA217320

Entities

People

  • George C. Tsokos

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Antibodies
  • Availability
  • Blood
  • Cardiovascular System
  • Cells
  • Classification
  • Contracts
  • Hematopoiesis
  • Laboratory Animals
  • Lymphatic System
  • Lymphocytes
  • Security
  • Stem Cells
  • T Lymphocytes
  • Test And Evaluation

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Toxicology/Environmental Toxicology