Acute Dermal Toxicity of Guanidine Hydrochloride in Rabbits

Abstract

The acute dermal toxicity of guanidine hydrochloride was evaluated in five male and five female New Zealand White rabbits. Guanidine hydrochloride (2 g/kg) was applied topically to the clipped dorsal skin surface for 24 hours. No compound-related deaths or clinical signs were observed; however, guanidine hydrochloride did produce dermal irritation, necrosis, and eschar formation under conditions of the study. Keywords: Acute dermal toxicity; Guanidine hydrochloride; Rabbits; Mammalian toxicology; Nitroguanidine; Propellants; Munitions; Explosives.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1989
Accession Number
ADA217345

Entities

People

  • Don W. Korte Jr.
  • Gerald F. Hiatt
  • Steven K. Sanso

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Body Weight
  • Chemical Analysis
  • Classification
  • Health
  • Health Services
  • Materials
  • Medical Personnel
  • New Zealand
  • Pathology
  • Propellants
  • Quarantine
  • Security
  • Toxicity
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology