Acute Oral Toxicity of Guanidine Hydrochloride in Mice

Abstract

The acute oral toxicity of guanidine hydrochloride was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose was 570.8 + or - 39.6 mg(base)/kg for male and 621.4 + or - 83.4 mg(base)/kg for female mice. Clinical signs included behavioral and respiratory changes. Behavioral signs observed were tremors, irritability, inactivity, disorientation, hyperactivity, jumping, and twitching. Respiratory changes included increases in rate and depth, and gasping. Lethality was observed only during the first 4.5 hours after dosing and clinical signs were observed primarily during the first 24 hours after dosing. These results place guanidine hydrochloride in the slightly toxic category. Keywords: Munitions; Acute oral toxicity; Guanidine hydrochloride; Mouse; Mammalian toxicology; Nitroguanidine; Triple base propellants; Explosives.

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Document Details

Document Type
Technical Report
Publication Date
Dec 29, 1989
Accession Number
ADA217618

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan
  • Gerald F. Hiatt

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acclimatization
  • Biomedical Research
  • Body Regions
  • Body Weight
  • Chemical Analysis
  • Classification
  • Health
  • Health Services
  • Lethal Dosage
  • Lung Diseases
  • Materials
  • Medical Personnel
  • Propellants
  • Quality Control
  • Statistical Analysis
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology