An Investigation of the Potential of 31-Phosphorus Nuclear Magnetic Resonance Spectroscopy to Predict Radiation Sensitivity

Abstract

The ability of in vivo 31-Phosphorus Nuclear Magnetic Resonance (31- PNMR) Spectroscopy to predict radiation sensitivity following both single and fractionated therapy was evaluated in this study. For Radiation Induced Fibrosarcoma (RIF-1) tumors either, in their natural state or treated with the vasodilator, hydralazine, an increase in the ratio of phosphocreatine to inorganic phosphate (PCr/Pi) and tumor pH were shown to be significantly correlated (p < 0.01) with radiation sensitivity to a single dose of 15 Grays (Gy) of radiation. After administration of hydralazine to reduce tumor blood flow or flunarizine to increase tumor blood flow, time dependent changes were observed in the 31-P NMR spectrum. After hydralazine, there was a significant (p < 0.01) decrease in PCr/Pi over time. The opposite pattern was seen for flunarizine i.e., decline in Pi, and an increase tumors was substantially greater(p < 0.05) than that of hydralazine treated tumors. Theses.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA217649

Entities

People

  • Cindy Bowser

Organizations

  • Air Force Institute of Technology

Tags

DTIC Thesaurus Topics

  • Air Force
  • Cancer
  • Cell Physiological Processes
  • Chemical Shifts
  • Chemical Synthesis
  • Chemistry
  • Environmental Health
  • Magnetic Resonance
  • Measurement
  • Medical Personnel
  • Membrane Lipids
  • Metabolism
  • Nuclear Magnetic Resonance
  • Quantum Properties
  • Radio Frequency
  • Resonant Frequency
  • United States

Fields of Study

  • Physics

Readers

  • Cardiovascular Physiology
  • Medical Imaging.
  • Oncology (Cancer Research).