Acute Oral Toxicity of DIGL-RP Solid Propellant in ICR Mice
Abstract
The acute oral toxicity of DIGL-RP solid propellant was determined in male and female ICR mice by using an oral gavage split-dose method. The MLD was 4176.1 + or - 116.6 mg/kg for male mice and 3447.5 + or - 42.1 mg/kg for female mice. DIGL-RP produced clinical signs that were attributed to its nitrate ester component, diethyleneglycol dinitrate. These signs included tremors, depression of reflexes, and inactivity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included urine staining (males), hunched posture, squinting, and rough coat. Most animals exhibited signs by 2-3 hours after dosing and either had died or the signs had cleared by 96 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place DIGL-RP in the slightly toxic class. Keywords: DIGL-RP solid propellant, Diethyleneglycol dinitrate, Mouse, mammalian toxicology, Propellants, Acute oral toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 08, 1989
- Accession Number
- ADA217711
Entities
People
- Conrad R. Wheeler
- Don W. Korte Jr.
- Larry D. Brown
- Yvonne C. Letellier
Organizations
- Letterman Army Hospital