The Effects of 7.5% NaCl/6% Dextran-70 on Coagulation and Platelet Function in Humans and Rabbits
Abstract
A solution of 7.5% NaCl and 6% Dextran-70 (HSD) administered intravenously gives short-term hemodynamic improvement in the treatment of hemorrhagic hypotension. Since dextrans have been reported to interfere with blood coagulation, the effects of HSD on the prothrombin time (PT), the activated partial thromboplastin time (APTT), platelet aggregation, and platelet concentration were studied. HSD mixed with human plasma in ratios of 1:5 and 1:10 caused a dose-dependent prolongation of the PT, but had no effect on the APTT, when compared with the corresponding saline controls. In separate mixing studies, the hypertonic saline but not the dextran component of HSD was associated with the PT prolongation. HSD decreased human platelet aggregation at the 1:5 dilution and the lower aggregation was associated with the hypertonic saline but not the dextran. In euvolemic and hemorrhaged rabbits administered 4 ml/kg of intravenous HSD the PT and APTT were unchanged. The platelet concentrations decreased slightly but remained within normal limits. The data from these studies indicate that in its intended use, HSD is expected to have minimal effect on blood coagulation. Keywords: Prothrombin time; Partial thrombin time; Platelets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 28, 1989
- Accession Number
- ADA217720
Entities
People
- Barbara A. Ryan
- James J. Summary
- John R Hess
- Michael A. Dubick
- Nena R. Bangal
Organizations
- Letterman Army Hospital