The Use of Hypertonic Saline/Dextran vs Lactated Ringer's Solution as a Resuscitation Fluid Following Uncontrolled Aortic Hemorrhage in Anesthetized Swine
Abstract
We tested the hypothesis that following aortotomy, the administration of hypertonic saline/dextran (HSD) will increase hemorrhage and mortality. In this study we also compared the effects of HSD to the standard therapy of attempting to replace three times the amount of lost blood with lactated Ringer's solution (LR). Twenty-four anesthetized Yorkshire swine underwent splenectomy and stainless steel wire placement in the infrarenal aorta and were instrumented with Swan-Ganz and carotid artery catheters. The wire was pulled, producing a 5 mm aortotomy and spontaneous intraperitoneal hemorrhage. The animals were randomly assigned to one of the three study groups: 1) Control group; 2) HSD group in which 6 min after aortotomy a 4 ml/kg mixture of 7.5% NaCl and 6% Dextran-70 was given intravenously (IV) over 1 min; 3) LR group in which 6 min after aortotomy 80 ml/kg LR was given IV over 9 min.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1989
- Accession Number
- ADA217726
Entities
People
- Charles E.W. Wade
- G. A. Millnamow
- J. O'benar
- S. P. Bruttig
- W. H. Bickell
Organizations
- Letterman Army Hospital