Dose Effect of HSD (Hypertonic Saline/Dextran) Survival Following Hemorrhage

Abstract

The comparative effectiveness of various dosages of hypertonic saline/dextran (HSD) for the treatment of severe hemorrhage was investigated in conscious swine bled 46 ml/kg over 15 min. Five minutes after the completion of hemorrhage, the animals were treated with 1, 2, 4 or 11.5 ml/kg HSD and were observed over the next 96 hours. The 11.5 ml dose was superior to all other doses, effecting 100% survival. Survival incidence with 4, 2 and 1 ml/kg was 83, 64 and 13%, respectively. In terms of survival time, the 11.5 and 4 ml doses were not significantly different. Therefore, optimum resuscitative effectiveness of HSD is achieved within the dose range of 4 to 11.5 ml/kg. Keywords: Military trauma research.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1989
Accession Number
ADA217727

Entities

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Anatomy
  • Availability
  • Biological Sciences
  • Cardiovascular System
  • Classification
  • Diseases And Disorders
  • Fluids And Secretions
  • Hemic And Immune Systems
  • Hemorrhage
  • Hypertonic
  • Hypotension
  • Jugular Vein
  • Military Research
  • Security
  • Veins

Fields of Study

  • Medicine

Readers

  • Nuclear and Radiation Engineering.
  • Trauma Surgery or Emergency Medicine.