Mechanisms of Chemical Modulation and Toxicity of the Immune System
Abstract
The final three and a half years of our research with 1,1- dimethylhydrazine (UDMH) have focused on delineating the mechanisms of UDMH- induced immunomodulation. Actions of UDMH which could correlate with its immunoenhancement effects include: 1.) Interference with interleukin 2 (IL2) activity by suppression of IL2 receptor expression; 2.) Nonspecific stimulation of intracellular ionized calcium levels in lymphocytes; 3.) Interference with activated macrophage suppressive effects (as evidenced by reversal of Corynbacterium parvum-induced immunosuppression, as well as interference with chemiluminescence and prostaglandin E2 production). Other mechanisms for the immunomodulatory effects of UDMH which were ruled out include: 1.) UDMH does not interfere with the production or activity of hydrogen peroxide, a 'normal' endogenous immunosuppressant; 2.) UDMH does not alter the absolute or relative numbers of the T-lymphocyte subsets L3T4 (helper cells), Lyt-2 (suppressor/ cytotoxic cells), or Thy1.2 (all T cells); 3.) Ia antigen (immune response antigen) expression is also not affected by UDMH. One other effect of UDMH is suppression of interleukin 1 (IL1) activity by interfering with IL1 receptor expression. We are still investigating the effects on lymphocyte membrane potential and on the production and activity of Soluble Immune Response Suppressor (SIRS).
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1989
- Accession Number
- ADA217783
Entities
People
- Melinda J. Tarr
Organizations
- Ohio State University