Hypobaric Hypoxia (380 Torr) Decreases Intracellular and Total Body Water in Goats
Abstract
The effect of 16 days of hypobaric hypoxia on body fluid distribution was studied in four unanesthetized adult goats (Capra lircus). Total body water (TBW), extracellular fluid volume (ECF), and plasma volume (PV) were determined with (3)H2O, (14C)-inulin, and indocyanine green, respectively. Blood volume (BV = PV x 100/100 - HEMATOCRIT), red cell volume (RCV = BV - PV), intracellular fluid (ICF = TBW - ECF) and interstitial fluid (ISF = ECF - PV) volumes were calculated. Body mass (-7.1%), TBW (-9.1%), and ICF volume (-14.4%) decreased, while ECF (+11.7%), and ISF (+27.7%) volumes increased with exposure (p < 0.05). The decrease in TBW accounts for 89% of the loss of body mass. Hematocrit increased from 24.0 + or - 1.0% SEM to 34.2 + or - 2.2% (p < 0.05). BV was unchanged; an increase in RCV (+39.5%) counterbalanced the decrease in PV (-15. 3%) (p < 0.05). Goats were similar to humans in that prolonged hypobaric hypoxia resulted in decreases in TBW volume, ICF volume, and PV. Keywords: High altitude; Total body water; Extracellular fluid; Plasma volume; RER.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA218192
Entities
People
- L. A. Trad
- L. J. Hubbard
- M. J. Durkot
- Reed W. Hoyt
- V. A. Forte Jr.
Organizations
- United States Army Research Institute of Environmental Medicine