The Relationship between Esmolol and the Onset and Duration of Action of Succinylcholine in Patients Undergoing General or Orthopedic Surgery

Abstract

The purpose of this study was to investigate a potential interaction between esmolol and succinylcholine. Specifically, the researcher investigated whether or not esmolol prolongs the onset and duration of action of succinylcholine (Sch). The investigator studied 25 adult, ASA I and II, male and female patients. Patients underwent orthopedic or general surgical procedures under general anesthesia requiring endotracheal intubation. All subjects received identical preoperative medication; glycopyrrolate 0.2 mg intravenous (IV). Statistical analysis revealed a significant slowing in onset of Sch induced muscle relaxation (p<.045). Conversely, there was no statistically significantly delay in 50% (p<.179) and 90% recovery (p<.109). However, statistical analysis indicated that esmolol did prolong the recovery from Sch induced neuromuscular blockade. Further investigation of this potential interaction is warranted. (KT)

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 1983
Accession Number
ADA218479

Entities

People

  • Paul J. Safara

Organizations

  • Air Force Institute of Technology

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Anesthesiology
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Cardiovascular Surgery
  • Cardiovascular System
  • Chemistry
  • Health Services
  • Medical Personnel
  • Muscular Diseases
  • Myocardial Ischemia
  • Neuromuscular Agents
  • Peripheral Nervous System

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.
  • Trauma or Military Medicine