External Factors, Produced by Growing Nerves, Trigger a Regenerative Response in a Non-Regenerative Central Nervous System: Purification and Mode of Action

Abstract

Mammalian central nervous system (CNS) neurons have negligible posttraumatic regenerative capacity while the nerves of lower vertebrates, as well as the pheripheral nervous system (PNS) of mammals regenerate spontaneously after injury. We found that application of soluble substances derived from growing nerves and of newborn rabbit optic nerves (in the form of conditioned media) to injured adult rabbit optic nerves resulted in alterations in neurons and their resident glial cells. In the course of our studies under this support, we succeeded to identify two activities within the active conditioned media derived from regenerating fish optic nerve and to purify a third molecular constituent, such as apolipoprotein-A-I. The two activities are an astrocyte- activating factor and an oligodendrocyte inhibitory factor. Lab animals; Rabbits; Fish-Carp; CNS; RA II; Mammals; Nervous systems; Neurons; Regeneration.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1989
Accession Number
ADA219218

Entities

People

  • Michal Schwartz

Organizations

  • Weizmann Institute of Science

Tags

DTIC Thesaurus Topics

  • Albumins
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Central Nervous System
  • Culture Media
  • Molecules
  • Nerves
  • Nervous System
  • Neuroglia
  • Neurons
  • Optic Nerve
  • Peptide Growth Factors
  • Peripheral Nervous System
  • Proteins
  • Sciatic Nerve
  • Spinal Cord

Fields of Study

  • Biology

Readers

  • Neuroscience