Discovery and Development of Therapeutic Drugs against Lethal Human RNA- Viruses: A Multidisciplinary Assault

Abstract

This study focused on discovery of new antiviral drugs. We have been pursuing the pancratistatin family of antiviral leads as a top priority. The research results have been very encouraging and pancratistatin, isonarciclasine, cis-dihydronarciclasine as well as trans-dihydronarciclasine have proved to be quite promising. Meanwhile over 1700 naturally occurring specimens are now undergoing preliminary antiviral evaluation at USAMRIID. The most exciting overall result has been the discovery in USAMRIID's laboratories that pancratistatin will cure the in vivo experimental version of Japanese encephalitis. Of the 1770 samples submitted during this period for pre-screen testing, we have received data for 875. Of these 150 samples displayed possible activity against either PT or YF or both for a total of 173 positive results.

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Document Details

Document Type
Technical Report
Publication Date
Feb 20, 1990
Accession Number
ADA219393

Entities

People

  • George R. Pettit

Organizations

  • Arizona State University

Tags

DTIC Thesaurus Topics

  • Acids
  • Alcohols
  • Alkanes
  • Anhydrides
  • Animals
  • Availability
  • Chemistry
  • Chlorides
  • Classification
  • Contracts
  • Elements
  • Laboratory Animals
  • Materials
  • Security
  • Silica Gels
  • Sponges
  • Viruses

Readers

  • Research Science/Academic Research
  • Software Engineering
  • Virology (or Medical Virology).