Development of Carcinogenesis Bioassay Models: Response of Small Fish Species to Various Classes of Carcinogens

Abstract

The project was designed to expand the usefulness and exploit the advantages of small fish carcinogenesis models. Studies have focused on two primary species, the Japanese medaka (Oryzias latipes) and the guppy (Poecilia reticulata). This report, arranged in referenced publication format, describes the following studies: (1) carcinogenesis tests with the halogenated hydrocarbon 1,1,2,2-tetrachloroethane (TeCE), (2) the heavy metal cadmium, and (3) the aromatic amine 2-acetylaminofluorene (AAF); hepatic metabolism studies with dibromide (EDB); (4) AAF and (5) ethylene and the occurrence of (6) thymic lymphoma and (7) acinar cell carcinomas of the exocrine pancreas. (EG)

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 14, 1989
Accession Number
ADA219485

Entities

People

  • William E. Hawkins

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Carcinoma
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fish
  • Organic Chemistry
  • Wildlife

Readers

  • Aquatic Ecology
  • Immunology
  • Toxicology/Environmental Toxicology